Gastric injury caused by low-dose aspirin therapy in consecutive Japanese patients: a prospective study.

Autor: Fukuda, Shoji, Hosaka, Shigeru, Ozawa, Naomi, Akita, Sam, Kashima, Toshitaka, Kimura, Sosuke, Akiyama, Junichi, Mizoue, Tetsuya
Zdroj: General Thoracic & Cardiovascular Surgery; May2012, Vol. 60 Issue 5, p275-279, 5p
Abstrakt: Purpose: Low-dose aspirin (<325 mg/day), administered to those with several conditions involving ischemic disorders, can cause upper gastrointestinal (GI) complications. In this prospective study, we aimed to clarify the incidence of aspirin-induced gastric ulcers in consecu tive Japanese patients and identify suitable preventive measures. Methods: We recruited 125 consecutive adult outpatients who received low-dose aspirin (enteric-coated tablets 100 mg) for >8 weeks. Endoscopy and blood tests were used to evaluate their gastric injury (which was scored using a modified Lanza scale) and anti- Helicobacter pylori antibody titer, respectively. Results: We found that 39.8% of patients received either no upper GI drug or only mucoprotective drugs, 39.8% received medium-dose histamine H2 blockers, and 20.4% received proton-pump inhibitors (PPIs). Anti- H. pylori antibody titers were positive in 43.7% of patients. The incidence of definitive gastric ulcers in this population was 0.97%. Ordered logistic regression analysis revealed that the odds ratio for the increase in the modified Lanza score was 0.20 for medium-dose histamine H2 blockers and 0.09 for PPIs. Conclusion: The incidence of postoperative definitive gastric ulcers in Japanese patients receiving ≤100 mg enteric-coated aspirin was 0.97%. The use of PPIs and histamine H blockers may prevent aspirin-induced gastric injury in such patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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