| Autor: |
Mendonça, Regina, Araújo, Marcela, Levy, Carlos, Morari, Joseane, Silva, Rosângela, Yunes, José, Brandalise, Silvia |
| Předmět: |
|
| Zdroj: |
Supportive Care in Cancer; May2012, Vol. 20 Issue 5, p1101-1107, 7p |
| Abstrakt: |
Background: Oral mucositis is a common collateral effect among the secondary complications resulting from chemotherapy. The objective of this study was to prospectively evaluate the association of HSV-1, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia (ALL). Procedure: Seventy-one prospective patients were included. Analyses of oral microbiota were conducted on days 14 (D14) and 56 (D56) of the Brazilian GBTLI-99 treatment protocol. Herpes simplex virus ( HSV) identification was performed by PCR followed by DNA sequencing analysis. Bacteria and fungi identification was obtained by standard microbiological culture tests. Results: HSV-1 was found in 10.37% of individual patient samples. One sample was positive for HSV-4. On D14, we found an association between the severity of mucositis and the presence of HSV ( p = 0.0347) and Candida spp. ( p = 0.0078). At D56, we found an association between the severity of mucositis and the presence of HSV on D14 ( p < 0.0001) and HSV presence ( p = 0.0317). Conclusion: The presence of HSV, mainly HSV-1, and Candida spp. was associated with mucositis severity in pediatric ALL. No association could be found between bacterial CFU and severity of mucositis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink