Follow-up of women with gestational diabetes in the Tehran Lipid and Glucose Study (TLGS): A population-based cohort study.

Autor:	Ramezani Tehrani, Fahimeh, Hashemi, Somayeh, Hasheminia, Mitra, Azizi, Freidoon
Předmět:	ANALYSIS of covariance BLOOD pressure BLOOD sugar CHI-squared test CHOLESTEROL GESTATIONAL diabetes HIGH density lipoproteins LONGITUDINAL method LOW density lipoproteins TYPE 2 diabetes PERINATAL death PROBABILITY theory RESEARCH funding STATURE TIME TRIGLYCERIDES U-statistics BODY mass index DISEASE incidence CASE-control method DISEASE progression FETAL macrosomia GLUCOSE intolerance DATA analysis software WAIST circumference DESCRIPTIVE statistics
Zdroj:	Journal of Obstetrics & Gynaecology Research; Apr2012, Vol. 38 Issue 4, p698-704, 7p, 3 Charts, 1 Graph
Abstrakt:	Aim: Women with gestational diabetes (GDM) are at increased risk of developing type 2 diabetes mellitus (T2DM), but there is disagreement regarding this conversion rate or its cardiovascular consequences. We investigated the metabolic and cardiovascular consequences of women with GDM in a population-based cohort study. Material and Methods: Three groups of women were selected from the Tehran Lipid and Glucose Study (TLGS) and followed up for an average 9 years: women with prior history of GDM ( n = 29); women with history of macrosomia or stillbirth without GDM (MC-ST) ( n = 570), and age- and BMI-matched controls ( n = 628). The incidence of T2DM, hypertension (HTN) and dyslipidemia were compared between these groups. Statistical significance was set at P < 0.05. Results: During the 9-year follow-up, T2DM was diagnosed in 27.3% of women with GDM in comparison to 9.5% among the control group ( P < 0/001); 7.4% of the MC-ST group versus 8.9% of control group developed T2DM during the study follow-up ( P = 0/03). There was no significant difference in the incidence of HTN or dyslipidemia between these groups ( P > 0/05). Conclusion: Women with a history of GDM are at higher risk for developing T2DM later in life. The timely recognition of GDM may provide a 'teachable moment' during which women could be motivated to implement lifestyle modifications to reduce their T2DM risk. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text