| Autor: |
Brissos, RosaFaustino, García, Silvia, Presa, Andreu, Gamez, Patrick |
| Předmět: |
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| Zdroj: |
Comments on Inorganic Chemistry; Sep-Dec2011, Vol. 32 Issue 5-6, p219-245, 27p, 16 Diagrams |
| Abstrakt: |
The present minireview deals with the use of the oxidative properties of copper(II/I) coordination compounds for valuable applications, namely the selective conversion of alcohols into aldehydes (or ketones), the cleavage of DNA strands (anti-cancer drugs), and the prevention of the formation of copper/amyloid plaques in Alzheimer's disease (AD). The concise report is therefore organized in three clearly defined parts: i) the design and preparation of simple copper(II) (and copper(I)) coordination compounds, mimicking the enzymatic activity of galactose oxidase, to mediate the selective oxidation of alcoholic substrates; ii) the generation of copper-containing chemical nucleases for the development of effective anti-cancer agents; iii) the current state of the art regarding the elucidation of the copper-based biological mechanisms (involving β-amyloid) that govern neural degeneration in AD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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