Estrogen receptor determinations in primary breast cancer.

Autor: Kleist, S., Berling, J., Koltzenburg, J., Gropp, H.
Zdroj: Journal of Cancer Research & Clinical Oncology; 1988, Vol. 114 Issue 6, p623-627, 5p
Abstrakt: The present study describes the estrogen receptor (ER) detection by an immunocytochemical assay kit (ER-ICA) on cryostat sections of 78 primary breast carcinomas. Results are compared with quantitatively measured ER levels, which were obtained by the dextran-coated charcoal (DCC) method. An excellent overall correlation between the logarithm of the ER levels, estimated by this technique, and the semiquantitative immunocytochemical evaluation was found, i.e. r=0.73. Since the ER-ICA can be easily handled without radioactivity being involved and since it is more representative of the total tumor, we conclude (as other groups before us) that the ER-ICA is an easy-to-handle and reliable technique presenting many advantages over the DCC method. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index