Heterogeneity of biotransformation of fluoranthene in perifused liver cells.

Autor: Stier, Anton, Schlenker, Arvid, Sidhu, Jaspreet, Kühnle, Wolfgang, Finch, Simon
Zdroj: Journal of Cancer Research & Clinical Oncology; 1988, Vol. 114 Issue 1, p39-46, 8p
Abstrakt: Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of β-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index