| Autor: |
Heidl, G., Davaris, P., Zwadlo, G., Jagoda, M., Düchting, S., Bierhoff, E., Grüter, T., Krieg, V., Sorg, C. |
| Zdroj: |
Journal of Cancer Research & Clinical Oncology; 1987, Vol. 113 Issue 6, p567-572, 6p |
| Abstrakt: |
Using monoclonal antibody 25 F 9, which reacts with a determinant of mature macrophages, the inflammatory infiltrate of 66 gastric carcinomas was evaluated using a counting grid. The ratio tumor cells/macrophages was determined for every tumor. For a threshold value of 5, carcinomas with a better prognosis, such as the intestinal type according to Lauré, the expanding type according to Ming and the differentiated carcinomas according to the WHO had a significantly smaller relative content of 25 F 9-positive macrophages (a minimum of P<0.05) than the diffuse type, infiltrative type, and undifferentiated carcinomas. Furthermore, the relative macrophage content tended to increase with the stage of carcinoma spread ( P<0.1). The results suggested that 25 F 9-positive macrophages in gastric carcinoma are of greater significance in tumor spread than in any defensive reaction against the tumor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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