| Autor: |
Morkeberg, Jean, Edmund, Carsten, Prause, Jan, Lanng, Susanne, Koch, Christin, Michaelsen, Kim |
| Zdroj: |
Graefe's Archive of Clinical & Experimental Ophthalmology; 1995, Vol. 233 Issue 11, p709-713, 5p |
| Abstrakt: |
• Background: Vitamin A deficiency with eye symptoms has been reported in patients with cystic fibrosis who received the recommended daily intake of vitamin A. • Methods: We measured serum retinol, dark adaptation, contrast sensitivity, and dry eye status in 35 adult cystic fibrosis patients to ascertain whether they had ocular signs or symptons. • Results: Median serum retinol concentration was 1.95 μmol/l, range 1.08-4.01 μmol/l, with no values indicating vitamin A deficiency. Retinal light sensitivity was normal. Nineteen patients had reduced contrast sensitivity. Conjunctival imprints all showed plenty of goblet cells, but were characteristic of dry eye in 42% of patients ( n=14). Decreased tear film stability was found in 49% ( n=17), tear production was low in 31% ( n=11), and 23% ( n=8) showed an increased amount of dying epithelial cells. Nine patients (26%) had keratocon-junctivitis sicca according to the Copenhagen criteria. • Conclusion: Our patients had no biochemical or clinical signs of vitamin A deficiency. We speculate that the high incidence of dry eye could be a primary manifestation of cystic fibrosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink