| Autor: |
Hadházy, P., Vizi, E., Magyar, K., Debreczeni, L., Hutás, I. |
| Zdroj: |
Lung; 1983, Vol. 161 Issue 1, p123-130, 8p |
| Abstrakt: |
The effects of indomethacin (IND) and PGI on the tone of human isolated pulmonary arteries were studied. Baseline tone of the vessels was increased by IND, electric stimulation (ES), norepinephrine (NE), prostaglandin F (PDF) or K-excess. This high tone was decreased by PGI in a concentration dependent manner. IC values (molar concentrations producing 50% relaxation) for PGI were in the same concentration range (10 to 58.8 nmoles/l). The potency of the relaxant effect of PGI was inversely related to the magnitude of tone induced prior to the addition of PGI and independent of the type of tone inducer. It is suggested that the relaxant effect of prostacyclin on human pulmonary artery may be of clinical importance in the treatment of conditions associated with a rise in pulmonary vascular resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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