| Abstrakt: |
Description of a case of diffuse pulmonary amyloidosis and benign monoclonal gammopathy in a 59-year-old woman. It was diagnosed by transbronchial lung biopsy. The patient was observed for three years. It has been reported [1-4] that multiple myelomatosis, M gradient in the serum or in the urine and Bence-Jones proteinuria can occur simultaneously with amyloidosis. Magnus-Levi 1931 [5] suspected the Bence-Jones protein was the fundamental component of amyloid. Glenner et al. [6] confirmed this supposition in 1970 by demonstrating the identity of purified proteins from amyloid tissue with the primary structure of human immunglobulin light chains. Pulmonary lesions were observed in monoclonal gammopathies [7] in pulmonary myeloma [8, 9, 10], multiple myelomatosis [11, 12, 13], lymphosarcoma [2], bronchial carcinoma [14, 15, 16] and lymphoid interstitial pneumonia [17]. Diffuse pulmonary amyloidosis, in contradistinction to tumor-simulating delimited deposits of amyloid in respiratory organs [18, 19], is extremely rare. We found only case reports [20, 21] in which the condition had been diagnosed post mortem. [ABSTRACT FROM AUTHOR] |
