Effects of repeated administration of the monoamine oxidase inhibitor phenelzine on the discriminability of d-lysergic acid diethylamide (LSD) and 1-( m-trifluoromethylphenyl) piperazine (TFMPP).

Autor: Cunningham, Kathryn, Carroll, Brenda, Appel, James
Zdroj: Psychopharmacology; 1986, Vol. 89 Issue 1, p134-135, 2p
Abstrakt: Rats trained to discriminate d-lysergic acid diethylamide (LSD; 0.08 mg/kg) or 1-( m-trifluoromethylphenyl) piperazine (TFMPP; 0.8 mg/kg) were treated with the monoamine oxidase inhibitor (MAOI) phenelzine (10 mg/kg/day) for 7 days. After a 24 h 'washout' period, they were challenged with the training drug (and dose) or saline, during extinction test sessions. Following 0.08 mg/kg LSD, LSD-trained rats responded primarily on the saline lever (29% drug-appropriate responding) while, after TFMPP (0.8 mg/kg), TFMPP-trained animals responded on the drug lever (75% drug-appropriate responding). These preliminary data suggest that, if serotonin receptors are involved in the behavioral effects of TFMPP, these receptors differ from those involved in the effects of LSD. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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