The treatment of tardive dyskinesia with baclofen.

Autor: Glazer, W., Moore, D., Bowers, M., Bunney, B., Roffman, M.
Zdroj: Psychopharmacology; 1985, Vol. 87 Issue 4, p480-483, 4p
Abstrakt: Thirty-one psychiatric outpatients with tardive dyskinesia (TD) on neuroleptic medication were followed in a double-blind, randomized trial comparing baclofen (30-90 mg per day) to placebo. A repeated measures analysis of variance revealed no statistical difference between the baclofen-treated group and the placebo group for the group and the placebo group for the total Abnormal Involuntary Movement Scale (AIMS) scores. There was a trend ( P=0.09) for an initial improvement, then a worsening of frequency counts across four visits. The authors attempt to explain this finding on the basis of information obtained from animal research. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index