| Autor: |
Meldrum, B., Anlezark, G., Adam, H., Greenwood, D. |
| Zdroj: |
Psychopharmacology; 1982, Vol. 76 Issue 3, p212-217, 6p |
| Abstrakt: |
Viloxazine HCl is evaluated as an anticonvulsant in a wide range of rodent seizure models and in the epileptic baboon ( Papio papio). In the maximal electroshock test, the oral ED for abolition of tonic extension was 9 mg/kg after 30-min pretreatment (mouse) rising to 30 mg/kg after 60 min (mouse and rat). Comparable ED values were also found for protection against tonic extension in the mouse induced by the administration of the chemical convulsants metrazole or 3-mercaptopropionic acid. In DBA/2 mice the ED for abolition of tonic extension during sound-induced seizures was 6.8 mg/kg IP (30-min pretreatment). Pharmacokinetic studies in the mouse showed peak plasma levels to occur 30 min following oral doses, with a mean half-life of 58 min. The anticonvulsant plasma concentration was within 0.5-1 μg/ml. In the baboon, significant protection against photomyoclonic responses is observed 1-2 h after viloxazine (2.6 mg/kg IV), during which period the plasma concentration was again 0.5-1 μg/ml. After administration of approximately ten-times this latter dose level, i.e. 24 mg/kg IV, a syndrome characterised by an abnormal EEG and, in some instances, seizure activity was observed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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