Dose dependent changes in propranolol half life when used as an adjunct to neuroleptic treatment.

Autor: Staniforth, D., Yorkston, N., Zaki, Saniha
Zdroj: Psychopharmacology; 1982, Vol. 76 Issue 1, p62-65, 4p
Abstrakt: Three investigations were made into the pharmacokinetics of propranolol when added to the existing phenothiazine regime of patients with schizophrenia. The plasma level was found to depart from a linear relation with dose range 80-1500 mg daily. The peak-to-trough half time was found to increase with increasing dose, and the half life of propranolol was also found to be dose-dependent. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index