High-affinity H-imipramine binding in platelets from untreated and treated depressed patients compared to healthy volunteers.

Autor: Raisman, Rita, Sechter, Daniel, Briley, Michael, Zarifian, Edouard, Langer, Salomon
Zdroj: Psychopharmacology; 1981, Vol. 75 Issue 4, p368-371, 4p
Abstrakt: Specific high-affinity binding of H-imipramine to human platelets possesses very similar characteristics to the sites previously described in animal and human brains. In a study comparing the binding of H-imipramine in platelets obtained from 39 control volunteers with 37 hospitalized, untreated, severely depressed patients, the maximal binding of H-imipramine was found to be significantly lower in the depressed population. There were no differences in the K values. After 7-15 days of treatment with tricyclic antidepressant drugs, there was an improvement in the degree of the depression but no significant change in the maximal H-imipramine binding. After an average of 50 days treatment, Hamilton ratings had returned to normal, but the H-imipramine binding values remained unchanged. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: