The effect of cholinergic antagonists on increases of spontaneous locomotor activity and body weight induced by the administration of morphine to tolerant rats.

Autor: Oka, Tetsuo, Nozaki, Masako, Hosoya, Eikichi
Zdroj: Psychopharmacology; 1972, Vol. 23 Issue 3, p231-237, 7p
Abstrakt: Increases both in spontaneous locomotor activity and in body weight were observed after the administration of morphine-HCl (100 mg/kg, i. p.) to tolerant rats. These signs were inhibited by pretreatment of the morphine-tolerant rats with cholinergic antagonists; the inhibition by scopolamine was greater than that by methscopolamine or atropine. These results suggest that both central and peripheral cholinergic mechanisms participate in the increases both in spontaneous locomotor activity and in body weight of tolerant rats after morphine administration. [ABSTRACT FROM AUTHOR]
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