| Autor: |
Avivi, Amiel, Chari-Bitron, Aviva |
| Zdroj: |
Psychopharmacology; 1970, Vol. 18 Issue 4, p407-411, 5p |
| Abstrakt: |
Surfacing and sinking reactions of minnows ( Gambusia affinis) allow the determination of chlorpromazine in aqueous solutions down to concentrations of 0.1 μg/ml. In a given volume of solution, neither sex nor number of the fish per tube have any effect on their response to the low doses. A twenty-fold augmentation in volume causes a two-fold increase in sensitivity. The time elapsing, from the beginning of immersion until onset of surfacing, increases with decreasing drug concentration. Partial recovery from the drug is obtained after washing of fish with tap water. Adaptation occurs when the fish are immersed for more than 48 hrs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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