| Autor: |
Bernstein, Bernard, Cancro, Lewis |
| Zdroj: |
Psychopharmacology; 1962, Vol. 3 Issue 2, p105-113, 9p |
| Abstrakt: |
The purpose of this experiment was to determine the nature and extent of drug-behavior interaction in animals trained under different temporal parameters of the same avoidance schedule. Three groups of four rats each underwent training in a nondiscriminated avoidance procedure. Failure to develop the conditioned avoidance response necessitated the dropping of one animal from Group II and one animal from Group III. Each group was trained and tested under different shock-shock and response-shock intervals. Group I was (S-S 5) (R-S 10), Group II (S-S 10) (R-S 20) and Group III (S-S 20) (R-S 40) seconds. Following an initial training period each group received eleven 3 hour sessions to permit stabilisation of the avoidance behavior. Following the stabilization sessions, each group received selected doses of chlorpromazine, chlordiazepoxide and α-pipradrol. The results of this experiment indicate that the parametric values employed in the behavioral schedule are significant factors affecting drug behavior. This interaction was observed not only in the stability of the behavior per se, but in the activity profile obtained by comparing the two behavioral indices used to describe the data. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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