| Autor: |
Sonnenblick, Amir, Shriki, Anat, Galun, Eithan, Axelrod, Jonathan, Daum, Hagit, Rottenberg, Yakir, Hamburger, Tamar, Mali, Bela, Peretz, Tamar |
| Zdroj: |
Clinical & Translational Oncology; Mar2012, Vol. 14 Issue 3, p232-236, 5p |
| Abstrakt: |
Background: Although lymph node-positive breast cancers are associated with poorer prognosis, individual patients may have different clinical outcomes. Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signalling pathways. The goal of this study was to determine the prognostic value of phosphorylated (tyrosine705)-STAT3 in node-positive breast cancer patients. Methods: Immunohistochemical analysis of Phospho-STAT3 was performed on a tissue microarray of breast cancer specimens. The expression pattern of Phospho-STAT3 was correlated with survival outcome, and clinical and pathological parameters. Results: Out of 125 interpretable tumours, positive Phospho-STAT3 nuclear expression was seen in 35 (28%) of tumours. There was no significant relationship between Phospho-STAT3 expression and clinical-pathological parameters including age, hormonal receptor status, grade and tumour size. Interestingly positive tumours had a significantly improved disease-free survival at 5 years ( p=0.035). Additionally, positive Phospho-STAT3 nuclear expression was correlated with significantly improved survival at both 5 years ( p=0.023) and 10 years ( p=0.026). Finally, in multivariate analyses Phospho-STAT3 was found to be an independent prognostic marker of overall survival in node-positive breast cancer patients. Conclusion: These findings support the role of Phospho-STAT3 as an important independent prognostic marker in node-positive breast cancer patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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