Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.

Autor:	Holm, R., Tanum, G.
Předmět:	PROTEIN metabolism CARRIER proteins COMPARATIVE studies IMMUNOHISTOCHEMISTRY RESEARCH methodology MEDICAL cooperation PHOSPHOTRANSFERASES PROGNOSIS PROTEOLYTIC enzymes RESEARCH SQUAMOUS cell carcinoma STAINS & staining (Microscopy) TRANSCRIPTION factors TRANSFERASES EVALUATION research ANAL tumors
Zdroj:	Virchows Archiv: European Journal of Pathology; 1996, Vol. 428 Issue 2, p85-89, 5p
Abstrakt:	Reduced expression of nm23/NDP kinase and increased expression of cathepsin D seem to be correlated with a high metastatic potential for a variety of malignancies. Nm23/NDP kinase and cathepsin D have been correlated with several clinical variables, including survival in 96 patients with squamous cell carcinoma of the anal canal. Immunohistochemical methods were used on paraffin-embedded biopsies. Seventy-six (79%) anal carcinomas were nm23/NDP kinase positive, whereas 35 (36%) and 28 (29%) of the cases were cathepsin D positive in tumor cells and stromal cells, respectively. We have found no indication that the extent of cathepsin D staining has any prognostic significance. The overall survival of patients with tumours positive for nm23/NDP kinase in the cytoplasm was significantly shorter than that of patients with anal carcinomas negative for nm23/NDP kinase. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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