| Abstrakt: |
The studty compares the effects of the three main types of the naturally occurring prostaglandins on renal blood flow, glomerular filtration rate, urine output, excretion of sodium, potassium, calcium and chloride, and on osmolar and free water clearance in dogs. The prostaglandins were infused into the renal artery in maximally effective doses. None of them influenced GFR significantly. PGA increased renal blood flow by an average of 32% despite a slight decrease of blood pressure, but had only weak effects on fluid and electrolyte excretion. PGF increased preferentially fluid and electrolyte excretion with only little effect on renal blood flow. PGE, however, increased both, blood flow through the kidney and excretion, and was more effective than both others, PGA and PGF. It is concluded that the prostaglandin involved in the regulation of renal hemodynamics would presumably be one of the A series whereas prostaglandins involved in the regulation of excretion would rather belong to the E or F series. [ABSTRACT FROM AUTHOR] |
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