| Abstrakt: |
The effect of either removing the clamped kidney or unclamping the renal artery on hypertension induced by partial constriction of one renal artery with (one-kidney Goldblatt hypertension) or without contralateral nephrectomy (two-kidney Goldblatt hypertension) was studied in rats, and the influence of unclamping on urinary water and electrolyte excretion was measured. In one-kidney Goldblatt hypertension, removal of the clamped kidney lowered blood pressure in the initial stage (first week), but had no significant effect on established hypertension. In contrast, unclamping rapidly and permanently normalized blood pressure in the chronic stage, and induced a transient, marked increase of urinary excretion of water, sodium and potassium. Ligating the ureter immediately before unclamping prevented the permanent (24 h) fall in arterial pressure, but did not abolish an initial (6 h) fall of blood pressure. In two-kidney Goldblatt hypertension, removal of the clamped kidney consistently caused a rapid return of the arterial pressure to normal, irrespective of the duration of hypertension, and unrelated to the excetory function of the contralateral kidney. Hypertensive rats of this type excreted significantly more sodium, potassium and water than control rats. Unclamping normalized blood pressure and did not significantly increase urinary sodium and water excretion, but sharply decreased potassium excretion. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink