Glucagon: Its effects on the hepatic arterial and portal venous beds in dogs.

Autor: Bashour, F., Geumei, Aida, Nafrawi, A., Downey, H.
Zdroj: Pflügers Archiv: European Journal of Physiology; 1973, Vol. 344 Issue 1, p83-92, 10p
Abstrakt: The effects of intravenous, intra-arterial and intraportal administration of glucagon on hepatic artery and portal vein flows were studied in anaesthetized dogs. Intravenous administration of glucagon (10 μg/kg) increased hepatic arterial and portal venous flows by 155% and 176% of the control value respectively. Intraarterial injection of glucagon increased hepatic artery flow and decreased its resistance. The hepatic arterial effect of glucagon was dose-dependent and was not abolished after β-adrenoceptor blockade by propranolol 1 mg/kg i.v., or after denervation. Intraportal injection of glucagon had no direct immediate (<15 sec) effect on portal venous flow or pressure. This was followed by an increase in portal vein flow and pressure reaching maximal response within 3-5 min. This late effect was most likely the result of the mesenteric vasodilator action of glucagon. It is concluded that glucagon posses a direct dilator action on the hepatic artery, and indirectly influences the portal venous circulation. Glucagon may have a physiological role in the hepatic vascular bed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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