| Autor: |
Tietz, H., Montag, T., Volk, H., Brose, E., Gantenberg, R., Weichold, F., Hiepe, T. |
| Zdroj: |
Parasitology Research; 1991, Vol. 77 Issue 7, p577-580, 4p |
| Abstrakt: |
As recently reported, Sarcocystis gigantea lectin (SGL) is a powerful mitogen and a polyclonal activator (Syn. S. ovifelis) of human peripheral B-cells. In the present study we investigated the reactivity of human T-helper (CD4) and T-suppressor (CD8) cells to SGL. Mononuclear cells (MNCs) from five newborns and six adults were examined cytofluorometrically for the expression of cell-surface differentiation and activation antigens using a set of seven monoclonal antibodies. In all, 96% of cord-blood and 81% of adult CD4 cells expressed receptors for interleukin-2 (Tac) after 64 and 164 h incubation, respectively, in the presence of SGL (50 μg/ml). The percentages of neonatal and adult Tac CD8 cells amounted to 67% and 59%, respectively. Major histocompatibility complex (MHC) class II antigens identified using the monoclonal anti-human leukocyte antigen (HLA)-DR antibody L243 were expressed on 30% (CD4) and 44% (CD8) of adult T-cells. Neonatal HLA-DR T-lymphocytes were not detectable. In parallel, functional tests were performed to examine cell proliferation and MNC antibody production. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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