| Autor: |
Woodtli, W., Hedinger, Chr |
| Zdroj: |
Virchows Archiv A Pathological Anatomy & Histology; 1974, Vol. 364 Issue 1, p93-110, 18p |
| Abstrakt: |
19 'endodermal sinus tumors' of infantile testes and 5 analogous testicular tumors in adults were studied. The histopathology and prognosis of these cases are shown. As Teilum postulated, the 'endodermal sinus tumor' should be a unilaterally developed teratoma mimicking embryonal yolk sac tissue. The histology seems to confirm that this tumor type is of teratomatous genesis. In one tumor specimen two dermoid cysts were found. Despite the characteristic morphology of the tumor tissue a histogenetic interpretation is not yet possible. A comparison of human embryonal yolk sac does not show any similarity to the tumor tissue. The term EDST is therefore not appropriate. In childhood the clinical course of the EDST is relatively good, although the tumor has to be classified as an undifferentiated teratoma. At present, 12 of the 19 children with EDST are alive and without recurrences from 7 months to 26 years after orchidectomy. In one of these patients a solitary lung metastasis wag diagnosed 2 1/4 years after operation and was removed by a lobectomy. In 7 children recurrences occurred within one year. None survived the third postoperative year. Our cases and a review of the literature show that the prognosis is aggravated by the length of symptom duration and with increasing age. Both factors may be related. In adults the clinical course is poor and may correspond to usual forms of undifferentiated teratomas in this age group. Only one of the 5 adults is alive and without metastasis 6 years after surgery. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
