| Autor: |
Mirouze, Jacques, Marchal, Georges, Orsetti, André, Jaffiol, Claude, Monnier, Louis, Baldet, Pierre, Piperno, Michel, Hedon, Bernard |
| Zdroj: |
Acta Diabetologica Latina; 1978, Vol. 15 Issue 3/4, p205-211, 7p |
| Abstrakt: |
In a 46-year old Caucasian woman, the authors report a B-cell adenoma with plasma immuno-reactive insulin (IRI) ranging from 10 to 32 µU/ml, despite severe spontaneous hypoglycemia. In a peroperative sample withdrawn from the portal vein, normal IRI (40 µU/ml) in the presence of high insulin-like activity (290 µU/ml) was observed by using a biological assay performed on rat epididymal fat tissue. Furthermore, this material did not cross-react with insulin antibodies and was undetectable in systemic venous samples. Although further identification by chromatographic extraction was not performed, the substance secreted by the tumor is probably identical to the non-suppressible insulin-like activity (NSILA) isolated by Froesch and responsible for hypoglycemia in a few cases of extrapancreatic tumors. The absence of this material in systemic samples indicates an immediate removal by a single passage through the liver. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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