Severe digoxin intoxication in a child treated by infusion of digoxin-specific Fab-antibody-fragments.

Autor: Rossi, R., Leititis, J., Hagel, K., Smolarz, A., Brandis, M., Leititis, J U, Hagel, K J
Zdroj: European Journal of Pediatrics; 1984, Vol. 142 Issue 2, p138-140, 3p
Abstrakt: Accidental digitalis ingestion in children is a rare, but potentially life-threatening emergency. We report the case of a 2 10/12-year-old boy with accidental ingestion of 6 mg beta-Acetyl-digoxin. Soon after admission, the boy developed sinus bradycardia, SA and AV-block, of increasing severity without circulatory impairment. As the serum digoxin level reached 21.7 ng/ml digoxin-specific Fab-antibody-fragments were used to bind free serum digoxin. Immediately after infusion, serum free digoxin was below the detection limit, whereas total digoxin peaked at 219 ng/ml 5 h thereafter. The arrhythmias did not subside totally, so that in addition, a transvenous pacemaker was placed, but never used. The antibody-infusion was well tolerated and the boy was discharged in good health. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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