In vivo experiments with a pH-ISFET electrode.

Autor: Schepel, S., Rooij, N., Koning, G., Oeseburg, B., Zijlstra, W., Schepel, S J, de Rooij, N F, Zijlstra, W G
Předmět:
Zdroj: Medical & Biological Engineering & Computing; 1984, Vol. 22 Issue 1, p6-11, 6p
Abstrakt: The stability and pH sensitivity of 19 intravascular pH electrodes for continuous monitoring have been investigated. The sensors were mounted in indwelling vascular catheters (7F) which were inserted into the arteries of seven anaesthetised and mechanically ventilated dogs. Variations in arterial pH, ranging from 6·82 to 7·72, were obtained by infusion of sodium bicarbonate and hydrochloric acid and by hyper/ hypoventilation with various volume fractions of carbon dioxide in the inspiratory gas mixture. The pH sensor output potential was compared with in vitro pH determinations of arterial blood samples. After an initial stabilisation period following their introduction into the arterial blood, the electrodes showed an average long-term drift of 2·3 mVh. When this drift was taken into account, a typical pH sensitivity of 50 mV per pH was found. The relationship between the electrode potentials and the in vitro pH values was linear and in almost all cases the correlation coefficient (r) was above 0·9. The electrodes responded rapidly enough to reflect breath-to-breath oscillations in pH. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index