Respiratory depression produced by injection of GABA into the fourth ventricle of rabbit.

Autor: Jian-zhong, Xiang, Cheng-jun, Huang
Zdroj: Acta Academiae Medicinae Wuhan; 1985, Vol. 5 Issue 1, p10-14, 5p
Abstrakt: The experiments were performed on 97 albino rabbits. GABA administered through injection into the fourth ventricle caused inhibition on respiratory movement or decrease in phrenic nerve discharge activity. Diazepam produced similar effects as GABA. GABA receptor antagonists, bicuculline and picrotoxin, could reverse the respiratory depressant effect of GABA. Either bicuculline or picrotoxin given alone caused an increase in respiration. These results suggest that endogeneous GABA might be an inhibitory neurotransmitter involved in the central regulation of respiration. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index