| Autor: |
Rao, Xiangrong, Li, Shen, Dai, Xiwen, Li, Jun |
| Zdroj: |
Chinese Journal of Integrated Traditional & Western Medicine; 2000, Vol. 6 Issue 4, p295-298, 4p |
| Abstrakt: |
Objective: To investigate the effect of Huan-shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor-β (TGF-β) in the remnant kidney of rats. Methods : Male Wistar rats, after 4 weeks of 5/6 nephrectomy, were divided into two groups at random, and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24-hours were observed at beginning, 6th week and 12th week of the experiment, and FN and TGF-β2 were assayed by immunohistochemical technique and computer assisted image analysis as well. Results : Serum SCr and urinary protein of 24-hours were increased significantly in the animals after 5/6 nephrectomy. The increased parameters decreased in the HSR group after treatment, as compared with those in the control group, and the difference was significant ( P < 0.05); Immunohistochemical measurement and computer assisted image analysis showed a marked suppression of FN and TGF-β in animals of the HSR group with significant difference from those in the control group (P<0.05). Conclusion : HSR not only plays the role of renal function protection, but could also alleviate the glomerular pathological injury. The effect on TGF-β2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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