| Autor: |
Lang, Jiangming, Cao, Haiwei, Wei, Aisheng, Huang, Biao, Tan, Feng, Wu, Jun |
| Zdroj: |
Chinese Journal of Integrated Traditional & Western Medicine; 2000, Vol. 6 Issue 1, p14-17, 4p |
| Abstrakt: |
Objective: To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and Ticlid in treating early diabetic nephropathy (DN). Method: Fifty-eight patients were divided randomly into two groups, 28 patients of the Ticlid group treated with Ticlid 250 mg orally, once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. The therapeutic effect and relative indexes of the two groups were observed and compared. Results: After treatment, in both groups, the thromboxane B markedly reduced and was more prominent in the Ticlid group (P<0.05), while the 6-keto-prostaglandin F increased obviously, so as to cause a significant lowering of T/K ratio, P<0. 01. Levels of urinary albumin, β microglobulin and blood ± microglobulin of both groups were lowered significantly, P<0. 01. A significant positive linear correlation was found in the Ticlid group between urinary albumin and T/K ratio (r = 0.41, P < 0.01), as well as in blood ± microglobulin with T/K ratio (r = 0. 34, P < 0.05), while it was not found in the PNG group. Conclusion: Ticlid and PNG were beneficial to resume the balance of T/K ratio and improve microcirculation, reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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