| Autor: |
Parmiani, Giorgio, Fossati, Giuseppe, Porta, Giuseppe |
| Zdroj: |
Ricerca in Clinica E in Laboratorio; 1980, Vol. 10 Issue 3, p481-492, 12p |
| Abstrakt: |
The data pertaining to the possible relationship between histocompatibility antigens (HA) and tumor-specific transplantation or tumor surface antigen (TSTA or TSA) are reviewed. The HA profiles of certain experimental and human neoplasms have been found to be altered either from the quantitative (increased expression of some antigenic specificities and decreased expression or even lack of other HA) or qualitative point of view (appearance of alien, genetically inappropriate HA). The authors entertain the possibility that the presence of TSTA or TSA on cancer cells may be linked to alterations of the HA profile. Evidence in favour of the idea that tumor antigens may actually be alien MHC products, alien minor HA or modified HA, is reviewed. Findings on structural relationships between TSA and β-microglobulin are also summarized. In the authors' opinion, no definitive conclusions can be reached at the present time on the relationship between TSTA or TSA and HA of cancer cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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