| Abstrakt: |
Earlier studies have shown that intraperitoneal injection of the industrial solvent sulfolane (tetrahydrothiophene-1,1-dioxide) caused a decrease in metabolic rate and a rapid, regulated hypothermia in mice and rats. In the present study, subcutaneous injections of 0, 100, 200, 400, 600, and 750 mg/kg sulfolane at an ambient temperature (T) of 10° C caused a dose-dependent decrease in colonic temperature (T) of rabbits. Metabolic rate (MR) remained unchanged during the initial phase of the hypothermia for all dose groups; but peripheral vasodilation, as indicated by an increase in ear skin temperature, was seen at the higher dose levels. The observed thermoregulatory response to sulfolane was a function of T. Thus, at Ts of 10 and 20° C, injection of 600 mg/kg sulfolane had no effect on MR but caused an increase in ear skin temperature. The magnitude of the hypothermia was similar at these two Ts, indicating the sulfolane-treated rabbits had some control over T. At a T of 28° C, however, the animals became hyperthermic upon injection of 600 mg/kg sulfolane. [ABSTRACT FROM AUTHOR] |
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