| Abstrakt: |
The fate of the four stereoisomers of soman [0-(1,2,2-trimethylpropyl)-methyl-fluoro phosphonate] has been studied a) in vivo in mouse blood and liver after IP injection of 0.75 × LD R- and S-soman respectively, and b) in vitro upon incubation wih acetyl- und pseudocholinesterase, aliesterase and phosphorylphosphatase. The analytical method used is based on gas chromatography - mass spectrometry with deuterated internal standard. Most soman disappeared very rapidly from blood and liver. In liver, SR and RR, the two isomers that preferentially react with cholinesterase, could be detected. The level of SR, which was higher than that of RR, could be followed for 17-18 h. In blood only SR could be detected. The amounts found were fairly constant during the time period 2 min to 4h, and it could even be detected 17-18 h after soman administration. [ABSTRACT FROM AUTHOR] |
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