| Abstrakt: |
In the giant interneurons of the spinal cord of the lamprey, Lampetra japonica, a primitive vertebrate, DL-α-aminoadipate, 3-5 mM, reversibly depressed both the monosynaptic EPSP and the depolarization produced by iontophoretic application of glutamate or aspartate. The monosynaptic EPSP was produced by intracellular stimulation of caudal giant interneurons. L-glutamate diethylester also depressed both the monosynaptic excitation and aspartate and glutamate potentials but 10-20mM was necessary. It seems likely that acidic amino acids or closely related substances may be serving the mutual excitation between giant interneurons of the lamprey spinal cord. [ABSTRACT FROM AUTHOR] |
