| Autor: |
Breer, H., Heilgenberg, H. |
| Zdroj: |
Journal of Comparative Physiology A: Sensory, Neural & Behavioral Physiology; Sep1985, Vol. 157 Issue 3, p343-354, 12p |
| Abstrakt: |
The biochemical elements of GABA-ergic synapses in the central nervous tissue were examined by a comparative neurochemical approach. The high concentration of GABA as well as the activities of glutamate decarboxylase and GABA-transaminase suppose a high content of GABAergic elements in the nervous system of the locust. Nerve endings isolated from the ganglia of locusts accumulated exogenous GABA in a carriermediated, sodium dependent process into compartments from where it could partially be released under depolarizing conditions. The transport was stimulated by extracellular chloride, was modulated by specific ionophores (enhanced by valinomycin, inhibited by CCCP) and could effectively be blocked by GABAergic ligands (DABA, muscimol). Binding studies revealed the existence of multiple binding sites for GABA which differ in number, affinity, pharmacology and ion dependency. The putative receptors for GABA (Na-independent binding sites) in locust nervous tissue exceeded the concentrations found in vertebrate brain tissue and showed different binding pharmacology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink