| Autor: |
Unwin, N., Shaw, J., Zimmet, P., Alberti, K. G. M. M. |
| Předmět: |
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| Zdroj: |
Diabetic Medicine; Sep2002, Vol. 19 Issue 9, p708-723, 16p |
| Abstrakt: |
Contents Glossary of abbreviations 708 Abstract 709 Introduction 710 Aim and objectives of the workshop 710 Structure of the report 711 Background 711 The origin and nature of IGT and IFG categories 711 Definitions 711 Descriptive epidemiology of IGT and IFG 712 The predictive properties of IFG and IGT—methodological considerations 713 Predictive properties of IGT and IFG for diabetes 713 Predictive properties of IGT and IFG for cardiovascular disease and total mortality 714 Predicting CVD and diabetes as outcomes from a ‘common soil’ 716 Intervention studies in people with impaired glucose tolerance 717 Identifying and prioritizing people with IGT for intervention 718 Consensus statements and recommendations 720 The Definition and Status of IGT and IFG 720 Diseases, risk factors or risk markers? 720 Should we intervene? 720 Acknowledgements 721 Appendix — Workshop members 721 References 721 Abstract A workshop was convened by the International Diabetes Federation to review the latest information relating to the risks associated with impaired glucose tolerance (IGT) and impaired fasting glycaemia (IFG) for future diabetes and cardiovascular disease (CVD). The workshop sought to address three questions: (i) are the current definitions of IGT and IFG appropriate; (ii) are IFG and IGT risk factors, risk markers or diseases; (iii) what interventions (if any) should be recommended for people with IFG and IGT? • The determinants of elevated fasting glucose and 2-h plasma glucose in an oral glucose tolerance test (2-HPG) levels differ. Raised hepatic glucose output and a defect in early insulin secretion are characteristic of the former, and peripheral insulin resistance is most characteristic of the latter. Therefore, it is not surprising that the concordance between the categories of IFG and IGT is limited. ▸ In all prevalence studies to date only half or less of people with IFG have IGT, and even a lower proportion... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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