Crystal structure of monomeric human Β-2-microglobulin reveals clues to its amyloidogenic properties.

Autor: Trinh, Chi H., Smith, David P., Kalverda, Arnout P., Phillips, Simon E.V., Radford, Sheena E.
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 7/23/2002, Vol. 99 Issue 15, p9771, 6p, 10 Diagrams, 2 Graphs
Abstrakt: Focuses on the dissociation of human B-2-microglobulin from the heavy chain of the class I human leukocyte antigen complex. Step in the formation of amyloid fibrils from the protein; Increase on the concentration of circulating monomeric B-2-microglobulin; Mechanism of amyloid formation from soluble native protein.
Databáze: Complementary Index