Lack of differences between the neuronal and extraneuronal handling of H-7- and H-ring-2,5,6-(−)noradrenaline.

Autor: Grohmann, M., Henseling, M.
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology; 1988, Vol. 338 Issue 2, p180-184, 5p
Abstrakt: The neuronal disposition of the side chain-labelled H-7-(−)noradrenaline and the ring-labelled H-2,5,6-(−)noradrenaline of relatively high specific activity was compared in the (incubated) rabbit aorta, the extraneuronal one in the (perfused) rat heart. Furthermore, the metabolism by monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT) of the labelled amines was studied in rat heart homogenates. In addition, some of the experiments were also carried out with the side chain-labelled H-7,8-(−)noradrenaline that is an inferior substrate of MAO. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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