| Autor: |
Koons, Jay, Long, John, Cannon, Joseph |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; 1984, Vol. 328 Issue 2, p180-185, 6p |
| Abstrakt: |
The pharmacological effects of three ergoline ftagments (BD-179, BD-271 and BD-214) were studied in vivo using the cat cardioaccelerator nerve preparation and in vitro using field stimulated isolated cat right atria. BD-179 and BD-271 produced dose dependent inhibition of tachycardia due to electrical stimulation of the right postganglionic cardioaccelerator nerve in anesthetized cats, BD-214 was inactive. BD-179 produced primarily hypotension, BD-271 produced a transient pressor response followed by hypotension and BD-214 produced only pressor effects. The tachycardia inhibitory effects and hypotension produced by BD-179 and BD-271 were antagonized by the dopamine receptor antagonist sulpiride. BD-179, BD-271 and BD-214 antagonized the presynaptic inhibitory effects of the dopamine receptor agonist apomorphine in vitro on field stimulated isolated cat right atria. All three ergoline fragments facilitated stimulation-induced increases in systolic tension development and BD-214 facilitated stimulation-induced tachycardia in isolated cat right atria. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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