| Autor: |
Brodde, Otto-Erich, Daul, Anton, O'Hara, Naoki |
| Zdroj: |
Naunyn-Schmiedeberg's Archives of Pharmacology; 1984, Vol. 325 Issue 2, p190-192, 3p |
| Abstrakt: |
In 10 healthy volunteers the effects of acute increases in concentrations of catecholamines in plasma induced by dynamic exercise (on a bicycle for 15 min at 80% of maximum heart rate) on lymphocyte β-adrenoceptor density (determined by (±)-iodocyanopindolol binding) and-responsiveness (determined by cyclic AMP responses to 10 μmol/l isoprenaline) were investigated. Immediately after exercise plasma catecholamines were increased about 4-fold; concomitantly receptor density and cyclic AMP production increased 55% and 65%, respectively. One hour after exercise β-adrenoceptor density and plasma catecholamines had reached values, which were not significantly different from preexercise values, while cyclic AMP production was significantly diminished. It is concluded, that acute increases in concentrations of catecholamines in plasma may increase β-adrenoceptor density and - responsiveness in human lymphocytes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink