Mode of action of antirheumatic drugs on the cyclic 3′,5′-AMP regulated glycosaminoglycan secretion in fibroblasts.

Autor: Peters, H., Dinnendahl, V., Schönhöfer, P.
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology; 1975, Vol. 289 Issue 1, p29-40, 12p
Abstrakt: The effect of non-steroidal anti-inflammatory drugs on formation and release of glycosaminoglycans (GAG) and cyclic 3′,5′-AMP levels was studied in embryonic mouse fibroblasts. The results were compared and correlated with the action of these drugs on cyclic 3′,5′-AMP-dependent as well as independent protein kinase obtained from bovine diaphragm. The results indicate that non-steroidal anti-inflammatory drugs may exert their effects on GAG formation by interfering with cyclic 3′,5′-AMP formation or function. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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