Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines.

Autor: Liebig, R., Bernauer, W., Peskar, B.
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology; 1974, Vol. 284 Issue 3, p279-293, 15p
Abstrakt: In sensitized perfused guinea pig lungs antigen (ovalbumin) released prostaglandins (Pgs) F and E, slow-reacting substance of anaphylaxis (SRS-A), and histamine. Furthermore, high amounts of the metabolite 15-keto-13,14-dihydro-PgF were found. Accordingly, perfusion of nonsensitized lungs with PgF and E resulted in extensive destruction of both substances. Simultaneously with the mediator release, very intense bronchospasm and pulmonary vascular constriction occurred. Administration of histamine in nonsensitized lungs resulted in Pg release. Isoproterenol as well as adrenaline prevented the anaphylactic mediator release, and concemitantly inhibited the spastic effects in the lungs. Propranolol reversed these actions of the catecholamines. Also indomethacin abolished the prostaglandin release, but increased the liberation of SRS-A. The findings are discussed in view of the contraregulatory function of adrenaline in anaphylaxis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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