Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of the non-specific membrane affinity of nine β-adrenergic blocking agents.

Autor: Hellenbrecht, D., Lemmer, B., Wiethold, G., Grobecker, H.
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology; 1973, Vol. 277 Issue 2, p211-226, 16p
Abstrakt: In order to characterize the non-specific membrane affinity of β-adrenergic blocking agents (phenylethanolamino- and phenoxypropanolaminoderivatives), hydrophobicity ( i. e. partition coefficients) and surface activity were determined as physicochemical properties of the drugs. Local anaesthetic activity (isolated frog nerve) and effects on myocardial conduction velocity (frog heart) were used as pharmacological parameters. In addition, the hydrophobicity of the β-sympatholytics was calculated according to the method of Hansch and Fujita (1964). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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