Über den Einfluß einer befristeten Unterbrechung der Nebennierendurchblutung auf das Verhalten der Catecholaminausscheidung und Catecholaminspeicherung des Nebennierenmarks.

Autor:	Liemann, F.
Zdroj:	Naunyn-Schmiedebergs Archiv für Pharmakologie und Experimentelle Pathologie; 1971, Vol. 268 Issue 2, p171-176, 6p
Abstrakt:	The effect of a change in the steady state of the biological structure of the suprarenal gland on catecholamine secretion, accumulation and biosynthesis by the adrenal medulla was examined in rabbits and compared with the metabolic status of energy metabolism. As disturbance of the steady state we chose ischemias of the suprarenal gland of up to 120 min. The normal values found were an adrenaline content of 383 μg/g and a noradrenaline content of 2.1 μg/g tissue. Adrenaline secretion was 0.106 μg/min. Under infusion conditions, this value was increased to 0.178 μg/min. 30 min after blood readmission the adrenaline levels had dropped to 80% of the initial value for 30 and 60 min of ischemia and to 40% of the initial value for 120 min of ischemia. Adrenaline secretion rose at the beginning of blood readmission and fell in the course of recovery. The kinetics of secretion will be discussed in a report later. A comparison of adrenaline levels at the end of ischemia with ATP levels showed that the catecholamine ATP complex remains stable even after 120 min and that ATP is not available for general metabolic reactions. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu