| Autor: |
Kroneberg, G., Stoepel, K. |
| Zdroj: |
Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie; 1962, Vol. 243 Issue 1, p36-43, 8p |
| Abstrakt: |
1. In spinal cats Guanethidine inhibits polysynaptic and monosynaptic reflexes. The inhibition reaches its maximum after 10-20 min after i.v. injection of Guanethidine and lasts for several hours, whereas the simultaneously registered contraction of the M. gastrocnemius on the other leg, evoced by stimulation of the peripheral stump of the N. ischiadicus, is depressed transiently and to a smaller extent. 2. After intraarterial injection of Guanethidine into the A. femoralis, the muscle contractions elicited by nervous or reflex stimulation are inhibited at once and to the same extent. 3. The effect of nervous stimulation is inhibited by smaller doses of Guanethidine injected intraarterially than that of direct stimulation of the muscle. This difference in response cannot be observed significantly in the isolated diaphragm preparation of rats. 4. In curarized spinal cats the contractions of the directly stimulated muscle are still depressed by guanethidine. 5. The results are discussed with respect to the sites of action of Guanethidine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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