Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient.

Autor: Cozzi, J., Chevret, E., Rousseaux, S., Pelletier, R., Benitz, V., Jalbert, H., Sèle, B.
Zdroj: Human Genetics; 1994, Vol. 93 Issue 1, p32-34, 3p
Abstrakt: Human sperm chromosomes from a 46,XY/ 47,XXY male were obtained using the technique of in vitro penetration of zona-free hamster eggs. The analysis of 543 sperm complements shows a significantly increased incidence (0.9%) of hyperhaploid gonosomal 24,XY sets, with a lack of the expected corresponding gonosomal hypohaploidies, and a normal rate of autosomal non-disjunctions. These results support the suggestion that 47,XXY cells are able to go through meiosis and to form spermatozoa. Only 24,XY sperm chromosomal constitutions were observed suggesting a preferential pairing of homologous sex chromosomes in 47,XXY spermatocytes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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