Highly polymorphic repeat marker within the β-amyloid precursor protein gene.

Autor: Zappata, Stefania, Petersen, Michael, König, Ulrich, Blaschak, Jillian, Chakravarti, Arvinda, Tassone, Flora, Serra, Angelo, Antonarakis, Stylianos, Brahe, Christina
Zdroj: Human Genetics; 1994, Vol. 93 Issue 1, p85-86, 2p
Abstrakt: We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the β-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivsl, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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