| Abstrakt: |
The present report is a comparative analysis of the choroid plexus cell surface under normal and experimental conditions which stimulate secretion of cerebrospinal fluid (CSF). The choroid cell surface, under normal conditions, contains cilia, ridges, and microvilli, the complexity of which varies widely from cell to cell. The intercellular clefts are rather constantly 200-400 Å across. After stimulation of CSF secretion, significant changes were observed. Pilocarpine injection leads to regularity in size and shape of the microvilli. CSF extraction and ATP injection, on the other hand, produce an expansion of the free surface which results in a complex labyrinth of ridges and swollen microvilli. Under all of these experimental conditions the intercellular gap is considerably widened. The probable significance of these findings, in relation to CSF secretion, is discussed. [ABSTRACT FROM AUTHOR] |
