An electron microscope study of the regenerating nerve fibers.

Autor: Estable, Clemente, Acosta-Ferreira, Walter, Sotelo, J.
Zdroj: Zeitschrift Für Zellforschung und Mikroskopische Anatomie; 1957, Vol. 46 Issue 4, p387-399, 13p
Abstrakt: Guinea pig sciatic nerves were severed in order to obtain a regenerative process of the nerve fibers. The animals were killed at different periods of time after the severing (24 hours, 6 days and 12 days) and the specimens obtained were prepared for electronmicroscopic study. The nerve fiber growing extremities (growing cones) were specially studied. The growing cones showed the following components: a) microvesicles; b) mitochondria; c) multivesicular bodies. The microvesicles are hollow elements of about 200 to 700 Å. They constitute the main component of the growing cone. The mitochondria were seen as elongated bodies of 80 mμ. They were seen in many cases changing to round dense bodies which appear to break-up in irregularly-shaped fragments. The multivesicular bodies were found present in most of the growing cones. Protoneurofibrils do not exist in the growing cone but a close relationship between microvesicles and protoneurofibrils was found in the segments next to the growing cone. The above-mentioned components were found in all growing cones, disregarding the time elapsed after the nerve severing. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index